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Differential Scanning Fluorimetry (DSF)

Differential Scanning Fluorimetry (DSF)

     

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What is Differential Scanning Fluorimetry (DSF)?
     
    Differential Scanning Fluorimetry (DSF) is a powerful technique for measuring protein thermal stability. By gradually heating a protein sample with a fluorescent dye, DSF detects unfolding events. A higher melting temperature (Tm) indicates greater stability, helping optimize formulations, guide manufacturing, and support drug development.
   
         
 
 

 

Broad Application of DSF
 

DSF enables rapid protein stability assessment across development stages. By identifying unstable conditions early, it reduces protein loss during purification, improves success rates, and accelerates downstream process and buffer development. Mycenax leverages DSF to streamline formulation and ensure robust, manufacturable drug candidates.
 
 
 
 

Key Advantages of DSF
 
 
 
 
 
 
Minimal Sample
 

  • Requires less than 3 mg of protein, ideal for early-stage development with limited material.

  • Enables manufacturability assessment without large-scale production.

  • Delivers reliable stability data with minimal sample input.
 
 
 

High-Throughput Screening
 

  • Screen 30+ buffer conditions in just 2 hours.

  • Digitalized data provides instant insights into optimal stability conditions.

  • Accelerates development timelines, saving time and resources.
 
 
 

Comprehensive Buffer and Excipient Evaluation
 

  • Applicable to multiple development stages.

  • Tests 1300+ buffer and excipient combinations to optimize formulation stability.

  • Identifies risks early, minimizing protein loss and enhancing downstream processes.
 
 
 

 

 What is Differential Scanning Fluorimetry (DSF)?  
     
  Differential Scanning Fluorimetry (DSF) is a powerful technique for measuring protein thermal stability. By gradually heating a protein sample with a fluorescent dye, DSF detects unfolding events. A higher melting temperature (Tm) indicates greater stability, helping optimize formulations, guide manufacturing, and support drug development.  
     
   
 
 
 

Broad Application of DSF
 

DSF enables rapid protein stability assessment across development stages. By identifying unstable conditions early, it reduces protein loss during purification, improves success rates, and accelerates downstream process and buffer development. Mycenax leverages DSF to streamline formulation and ensure robust, manufacturable drug candidates.
 
 
 
 
 
 
 

Key Advantages of DSF
 
 
 
Minimal Sample
 

  • Requires less than 3 mg of protein, ideal for early-stage development with limited material.

  • Enables manufacturability assessment without large-scale production.

  • Delivers reliable stability data with minimal sample input.
 
 

High-Throughput Screening
 

  • Screen 30+ buffer conditions in just 2 hours.

  • Digitalized data provides instant insights into optimal stability conditions.

  • Accelerates development timelines, saving time and resources.
 

Comprehensive Buffer and Excipient Evaluation
 

  • Applicable to multiple development stages.

  • Tests 1300+ buffer and excipient combinations to optimize formulation stability.

  • Identifies risks early, minimizing protein loss and enhancing downstream processes.
 

 
 
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